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Our laboratory demonstrated that SERT and αvβ3 receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβ3 in midbrain synapses. Preceding studies recommend that in platelets, the association of SERT with activated αIIbβ3 integrins, and its localization to adhesion complexes, are correlated with amplified uptake action (Carneiro et al.
scores for synapses favourable for SERT/talin colocalization (knowledge offered on the top of graph because the imply ± SEM; unpaired t
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